4-Methylmorpholine → HCID 19603190, compound

Participants

Reaction Steps

The title compound of Example 3 (0.15 g, 0.31 mmol) was dissolved in CH2Cl2 (1.5 mL). 4-Methylmorpholine (102 uL), followed by mesyl chloride (36 uL, 0.47 mmol, 1.5 equiv.) was then added. Reaction mixture was stirred at room tempearture ovemite. The CH2Cl2 phase was washed twice with Sat. NaHCO3, brine and then dried over Na2SO4. CH2Cl2 was then removed by rotary evaporation and resulting residue was purified on silica gel column eluting with 30% EtOAc/CH2Cl2 to give the title compound as a white solid (0.109 9, mp=120-140° C., MH+==562.

Provenance & Evidence