HCID 11279119, compound → HCID 9840899, compound

Participants

Reaction Steps

A warm solution of 2-(4′-fluorophenyl)-4-[4′-(1-dimethylamino-2-propyn-3-yl)phenyl]thiazole (0.2 g, 0.6 mmol) in abs. EtOH (20 mL) containing a catalytic amount of palladium on activated carbon (5%, 20 mg) is shaked under hydrogen atmosphere (30 psi) for 2 h. After removal of the catalyst by filtration, the filtrate is concentrated to give 2-(4′-fluorophenyl)-4-[4′-(3-N,N-dimethylaminopropyl)phenyl]thiazole as desired product (0.18 g, 89%)

Provenance & Evidence