HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2-(3'-Nitrophenyl)-4[(3'-methoxy)phenyl]thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Phenacyl bromide | HCID 6259 | — |
| Reactant | 3-Nitrobenzene-1-carbothioamide | HCID 12668182 | — |
| Product | 2-(3'-Nitrophenyl)-4[(3'-methoxy)phenyl]thiazole | HCID 22611065 | — |
Reaction Steps
A mixture of 3-nitrobenzenethioamide (2.73 g, 15 mmol) and 3-methoxy-α-[bromoacetophenone (3.43 g, 15 mmol) in EtOH (30 mL) is heated under reflux for 18 h. It is cooled and filtered to give 4 g of 2-(3′-nitrophenyl)-4[(3′-methoxy)phenyl]thiazole as a yellow solid, mp. 122-123° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06277873B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-87817767b48141b182f4c604a80c80ee |
| Source note | uspto-grants-2001_08 |