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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 651018Generated: October 30, 2026

4-Chloro-2-[(ethoxycarbonyl)amino]benzonitrile → 3-Amino-6-chloro-2-(4-chloropyridine-2-carbonyl)-1-(ethoxycarbonyl)indole

https://huagongshe.com/reaction/651018

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-2-[(ethoxycarbonyl)amino]benzonitrileHCID 18367888—
Reactant2-Bromo-1-(4-chloro-pyridin-2-yl)-ethanone hydrobromideHCID 23003349—
Product3-Amino-6-chloro-2-(4-chloropyridine-2-carbonyl)-1-(ethoxycarbonyl)indoleHCID 18368177—

Reaction Steps

The title compound was prepared according to the procedure described in step 2 of Example 1 from 4-chloro-2-[(ethoxycarbonyl)amino]benzonitrile (Example 1, step 1) and 2-(bromoacetyl)4-chloropyridine hydrobromide*.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06277878B1
Source datasetuspto-grants-2001_08
ORD IDord-507a9214f99241078040323b3c30c341
Source noteuspto-grants-2001_08