Methanesulfonyl chloride → N-[2-(3-Bromobenzoyl)-6chloro-1H-indol-3-yl]methanesulfonamide

HRID 651030Notes

Reaction equation

HRID 651030 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[N:4](C(OCC)=O)[C:3]=1[C:17](=[O:25])[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([Br:24])[CH:19]=1.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>>[Br:24][C:20]1[CH:19]=[C:18]([CH:23]=[CH:22][CH:21]=1)[C:17]([C:3]1[NH:4][C:5]2[C:10]([C:2]=1[NH:1][S:27]([CH3:26])(=[O:29])=[O:28])=[CH:9][CH:8]=[C:7]([Cl:11])[CH:6]=2)=[O:25]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 183679223-Amino-2-(3-bromobenzoyl)-6-chloro-1-(ethoxycarbonyl)indole

Product 1

HCID 9845443N-[2-(3-Bromobenzoyl)-6chloro-1H-indol-3-yl]methanesulfonamide

Procedure

The title compound was prepared according to the procedure described in Example 38 from ethyl 3-amino-2-(3-bromobenzoyl)-6-chloro-1H-indole-1-carboxylate (step 1) and methanesulfonyl chloride.

Sources & evidence

ORD record
ord-e40027d82eab4efc97cede0fcd0bae51
Source dataset
uspto-grants-2001_08
Patent number
US06277878B1

Reaction notes

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