Methanesulfonyl chloride → N-[5-chloro-2-(3-chlorobenzoyl)-1H-indol-3-yl]methanesulfonamide

HRID 651034Notes

Reaction equation

[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[N:4](C(OCC)=O)[C:3]=1[C:17](=[O:25])[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=1.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>>[Cl:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][C:3]([C:17](=[O:25])[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([Cl:24])[CH:19]=1)=[C:2]2[NH:1][S:27]([CH3:26])(=[O:29])=[O:28]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 183677413-Amino-5-chloro-2-(3-chlorobenzoyl)-1-(ethoxycarbonyl)indole

Product 1

HCID 9886289N-[5-chloro-2-(3-chlorobenzoyl)-1H-indol-3-yl]methanesulfonamide

Procedure

The title compound was prepared according to the procedure described in Example 38 from 3-amino-5-chloro-2-(3-chlorobenzoyl)-1-ethoxycarbonyl-1H-indole (step 1) and methanesulfonyl chloride.

Sources & evidence

ORD record: ord-2bb146d6bc774cef8b869b17763d7a2a
Source dataset: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06277878B1

Reaction notes

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