Triethylamine → HCID 21710564, compound

Participants

Reaction Steps

To a stirred solution of the product from Example 19B (416 mg, 2.0 mmol) in 4 mL of dichloromethane at 0° C. was added triethylamine (0.34 mL, 2.4 mmol) followed by the addition of methanesulfonyl chloride (0.17 mL, 2.2 mmol). The mixture was placed in a refrigerator overnight. The resulting cloudy mixture was diluted with ethyl acetate and extracted with water, 3N aqueous HCl, water and brine, dried (Na2SO4), filtered, and concentrated to provide 552 mg (96%) of the title compound as an oil that was used directly.

Provenance & Evidence