Sodium Hydroxide → HCID 23506768, compound

HRID 651081Notes

Reaction equation

C[O:2][C:3](=[O:28])[C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[C:6]([CH3:11])[C:5]=1[N:12]([CH3:27])[S:13]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH:23]([CH3:26])[C:24]#[CH:25])=[CH:18][CH:17]=1)(=[O:15])=[O:14].[OH-].[Na+]>>[Br:10][C:8]1[CH:7]=[C:6]([CH3:11])[C:5]([N:12]([CH3:27])[S:13]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH:23]([CH3:26])[C:24]#[CH:25])=[CH:18][CH:17]=2)(=[O:15])=[O:14])=[C:4]([CH:9]=1)[C:3]([OH:28])=[O:2]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 88045278HCID 88045278, compound

Product 1

HCID 23506768HCID 23506768, compoundYield 31.2%

Procedure

According to the procedure of Example 10, 0.241 g of the product of Example 77 was hydrolyzed with 2.6 mL of 1.0N sodium hydroxide solution to provide 0.073 g (31%) of the desired carboxylic acid as a white solid and 0.034 g (14%) of the starting ester. Electrospray Mass Spec 451.8 (M+H)+

Sources & evidence

ORD record: ord-48ad8051c1d4445790915834b16f8504
Source dataset: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06277885B1

Reaction notes

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