HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl L-phenylalaninate hydrochloride → HCID 10546217, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl L-phenylalaninate hydrochloride | HCID 75736 | — |
| Reactant | 5-Chloro-1H-indole-2-carboxylic acid | HCID 82693 | — |
| Product | HCID 10546217 | HCID 10546217 | — |
Reaction Steps
L-Phenylalanine methyl ester hydrochloride (77.0 mmol) and 5-chloro-1 H-indole-2-carboxylic acid (77 mmol) were coupled according to procedure A (0-25° C.) and the product purified by chromatography on silica gel in 10 and 20% ethyl acetate-hexanes giving the title substance as an off-white solid (22.12 g, 81%): mp 156-157° C.; HPLC (60/40) 9.5 minutes (98%); PBMS 357/359 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06277877B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-69dba2ab55ab4b6eb9c3e6f75e917bb1 |
| Source note | uspto-grants-2001_08 |