4-Hydroxypyrrolidine → HCID 10179865, compound

Participants

Reaction Steps

Racemic3-pyrrolidinol (2.0 mmol) and 2-[(5-chloro-1H-indole-2-carbonyl)-amino]-3phenyl-propionic acid (1 mmol) were coupled according to procedure A (0-25° C. reaction temperature, washing first with acid then base), and the product purified by column chromatography on silica gel eluted with 0.5-16% ethanol in dichloromethane to give a colorless foam: Yield 260 mg, 63%; HPLC (60/40) 100%, 3.86 minutes; PBMS 412/414 (MH+, 100%);

Provenance & Evidence