HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidin-4-ol → HCID 53842654, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidin-4-ol | HCID 79341 | — |
| Reactant | tert-butyl N-[(2R)-1-oxo-3-phenylpropan-2-yl]carbamate | HCID 7020444 | — |
| Product | HCID 53842654 | HCID 53842654 | — |
Reaction Steps
(R)-2-(N-t-butoxycarbonylamino)-3-phenyl-propan-1-one (14 mmol) and 4-hydroxypiperidine (21.5 mmol) were coupled according to Procedure A (0-25° C. reaction temperature, washed with acid first then base) and the product used without further purification. Yield 4.7 g, 94%; HPLC (60/40) 3.52 minutes (98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06277877B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-4aeb4d9d47704881b57901abaceeac2a |
| Source note | uspto-grants-2001_08 |