Thiazolidine → HCID 21970176, compound

HRID 651118Notes

Reaction equation

HRID 651118 reaction equation
[S:1]1[CH2:5][CH2:4][NH:3][CH2:2]1.[C:6]([NH:13][C@H:14]([C:22](O)=[O:23])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7]>>[C:9]([O:8][C:6](=[O:7])[NH:13][C@@H:14]([CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:22](=[O:23])[N:3]1[CH2:4][CH2:5][S:1][CH2:2]1)([CH3:12])([CH3:10])[CH3:11]

Participants

3

Reactant 2

HCID 10444ThiazolidineHCID 77857L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-

Product 1

HCID 21970176HCID 21970176, compound

Procedure

Thiazolidine (38 mmol) and Boc-L-phenylalanine (19 mmol) were coupled according to Procedure A (0-25° C. reaction temperature, washed with acid then base) and the product used without further purification. Yield 5.5 g, 86%.

Workup

  1. custom0-25° C. reaction temperature
  2. washwashed with acid
  3. custombase) and the product used without further purification

Sources & evidence

ORD record
ord-3631dfa583594d358524c17cbc289d73
Source dataset
uspto-grants-2001_08
Patent number
US06277877B1

Reaction notes

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