Hydrochloric Acid → HCID 9797312, compound

Participants

Reaction Steps

2-Amino-1-thiazolidin-3-yl-ethanone hydrochloride (3.1 mmol) and 5-chloro-1H-indole-2-carboxylic acid (3.4 mmol) were coupled according to Procedure A (0-25° C., 120 hour reaction time) substituting the following work up: the reaction mixture was stirred with ethyl acetate and 2N HCl, filtered, and the filtered solid washed with 2N HCl, 2N NaOH and ether. Yield 988 mg, 98%; HPLC (70/30) 3.25 minutes (99%); mp 253-255° C. (dec, darkening at 243° C.); PBMS 324/326 (MH+, 100%);

Provenance & Evidence