HCID 10497933, compound → HCID 69688479, compound

HRID 651124Notes

Reaction equation

HRID 651124 reaction equation
C(OC(=O)[NH:7][C@@H:8]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:9]([N:11]1[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13][CH2:12]1)=[O:10])(C)(C)C.[ClH:26].O1CCOCC1>>[ClH:26].[NH2:7][C@@H:8]([CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[C:9]([N:11]1[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13][CH2:12]1)=[O:10]

Participants

3

Reactant 2

HCID 10497933HCID 10497933, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 69688479HCID 69688479, compound

Conditions

Temperature
25 °C

Procedure

(S)-[1-Benzyl-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester (3.66 g, 10.5 mmol) was dissolved in 4M HCl-dioxane (39 mL) at 0° C. The mixture was stirred at 25° C. for 1 hour, concentrated and the residue triturated with ether. Yield 3.06 g, 102%.

Workup

  1. concentrationconcentrated
  2. customthe residue triturated with ether

Sources & evidence

ORD record
ord-889d35d6face4119ab34f0bfd97df61b
Source dataset
uspto-grants-2001_08
Patent number
US06277877B1

Reaction notes

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