Triethyl orthoacetate → HCID 13519881, compound

Participants

Reaction Steps

A mixture of 2.5 g (0.015 mole) of 4-hydrazino-2-methyl-6-methythiopyrimidine and 50 ml of triethyl orthoacetate was heated at its reflux temperature for five days, and was then cooled. The solid was separated by filtration and recrystallized with treatment with decolorizing charcoal from first an ethyl acetate-hexane mixture, and then a benzene-hexane mixture to provide 3,5-dimethyl-7-methythio-1,2,4-triazolo[4,3-c]pyrimidine, m.p. 201°-203° C. Calculated for C8H10N4S: %C, 49.5; %H, 5.2; %N, 28.8; Found: %C, 49.6; %H, 5.2; % N, 28.9.

Provenance & Evidence