1,4-Dioxane hydrochloride → HCID 69687368, compound

HRID 651140Notes

Reaction equation

HRID 651140 reaction equation
C(OC(=O)[NH:7][C@@H:8]([CH2:18][C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)[C:9]([N:11]1[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13][CH2:12]1)=[O:10])(C)(C)C.[ClH:26].O1CCOCC1>>[ClH:26].[ClH:26].[NH2:7][C@@H:8]([CH2:18][C:19]1[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=1)[C:9]([N:11]1[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13][CH2:12]1)=[O:10]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21970177HCID 21970177, compound

Product 1

HCID 69687368HCID 69687368, compound

Conditions

Temperature
25 °C

Procedure

(S)-[2-(4-Hydroxy-piperidin-1-yl)-2-oxo-1-pyridin-3-ylmethyl-ethyl]-carbamic acid-tert-butyl ester (367 mg, 1.05 mmol) was dissolved in 4M HCl-dioxane at 0° C. The resulting suspension was stirred for 1.5 hours at 25° C., concentrated and the residue triturated with ether. Yield, 450 mg, 100%.

Workup

  1. concentrationconcentrated
  2. customthe residue triturated with ether
  3. customYield

Sources & evidence

ORD record
ord-424136d0fbfb4097bd7f9bac12203549
Source dataset
uspto-grants-2001_08
Patent number
US06277877B1

Reaction notes

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