HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 651147Generated: October 31, 2026
1,4-Dioxane hydrochloride → (S)-2-Amino-3-(4-amino-phenyl)-N,N-dimethyl-propionamide dihydrochloride
https://huagongshe.com/reaction/651147
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | (S)-[2-(4-Amino-phenyl)-1-dimethylcarbamoyl-ethyl]-carbamic acid tert-butylester | HCID 20679220 | — |
| Product | (S)-2-Amino-3-(4-amino-phenyl)-N,N-dimethyl-propionamide dihydrochloride | HCID 69688157 | — |
Reaction Steps
(S)-[2-(4-Amino-phenyl)-1-dimethylcarbamoyl-ethyl]-carbamicacidtert-butyl ester (214 mg, 0.7 mmol) was dissolved in 4M HCl-dioxane (2 mL) at 0° C. and the solution stirred for 2 hours at 25° C. The mixture was concentrated and the residue triturated with ether. Yield, 294 mg, 102%; PBMS 208 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06277877B1 |
|---|
| Source dataset | uspto-grants-2001_08 |
|---|
| ORD ID | ord-b9b0b5974e93460593f803e1fe51355f |
|---|
| Source note | uspto-grants-2001_08 |
|---|
