HCID 15458722, compound → HCID 66652331, compound

HRID 651160Notes

Reaction equation

HRID 651160 reaction equation
C(OC(=O)[NH:7][C@@H:8]([CH3:17])[C:9]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=[O:10])(C)(C)C.[ClH:19].O1CCOCC1>>[ClH:19].[NH2:7][C@@H:8]([CH3:17])[C:9]([N:11]1[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1)=[O:10]

Participants

3

Reactant 2

HCID 15458722HCID 15458722, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 66652331HCID 66652331, compound

Procedure

((1S)-Methyl-2-morpholin-4-yl-2-oxo-ethyl)-carbamic acid tert-butyl ester (3.88 g, 15 mmol) was dissolved in 4M HCl-dioxane (20 ml) at 25° C. for 1.25 hours. The mixture was concentrated and the residue triturated with ether and dried: Yield 2.51 g, 86%.

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue triturated with ether
  3. customdried

Sources & evidence

ORD record
ord-75934ec3124a481c8f4c3ff696b7ebf6
Source dataset
uspto-grants-2001_08
Patent number
US06277877B1

Reaction notes

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