HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → N-(2-amino-2-oxoethyl)-5-chloro-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | methyl N-[(5-chloro-1H-indol-2-yl)carbonyl]glycinate | HCID 4893740 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(2-amino-2-oxoethyl)-5-chloro-1H-indole-2-carboxamide | HCID 4028518 | — |
Reaction Steps
[(5-Chloro-1H-indole-2-carbonyl)-amino]-acetic acid methyl ester (100 mg, 0.40 mmol) was added to a saturated solution of ammonia in methanol (ca. 3 mL) at 25° C. The suspension was sonicated for 1 hour and the resulting solution concentrated. The residue was triturated with ether/hexanes and dried. Yield 77 mg, 77%; HPLC (60/40) 2.78 minutes (98%); PBMS 252/254 (MH+, 100%);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06277877B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-f94a54465e9d4d12beddd5a8eaf8728d |
| Source note | uspto-grants-2001_08 |