Chlorotrimethylsilane → HCID 2737507, compound

HRID 651168Notes

Reaction equation

HRID 651168 reaction equation
[S:1]1[CH2:5][CH2:4][NH:3][CH:2]1[C:6]([OH:8])=[O:7].Cl[Si](C)(C)[CH3:11]>CO>[CH3:11][O:7][C:6]([CH:2]1[NH:3][CH2:4][CH2:5][S:1]1)=[O:8]

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 424861,3-Thiazolidine-2-carboxylic acid

Product 1

HCID 2737507HCID 2737507, compoundYield 125%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (±)-thiazolidine-2-carboxylic acid (1.58 g, 11.9 mmol) and chlorotrimethylsilane (5.1 g, 47 mmol) in methanol (22 mL) was heated at reflux for 5 hours, cooled, and concentrated giving a solid (2.19 g, 100%).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 5 hours
  3. temperaturecooled
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-56c208e47e2d4f58a49d29d13e82c985
Source dataset
uspto-grants-2001_08
Patent number
US06277877B1

Reaction notes

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