HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 651187Generated: October 30, 2026
1-Hydroxybenzotriazole → HCID 54058721, compound
https://huagongshe.com/reaction/651187
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 5-Chloro-1H-indole-2-carboxylic acid | HCID 82693 | — |
| Reactant | Methyl 2-(2-amino-3-phenylpropanamido)acetate | HCID 351658 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 54058721 | HCID 54058721 | — |
Reaction Steps
To 5.0 mmol of 5-chloro-1H-indole-2-carboxylic acid (50 mL of a 0.1 M solution in acetonitrile) was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (50 mL of a 0.10 M solution in acetonitrile, 5.0 mmol), 1-hydroxybenzotriazole (50 mL of a 0.10 M solution in acetonitrile, 5.0 mmol), followed by (2-amino-3-phenyl-propionylamino)-acetic acid methyl ester (50 mL of a 0.10 M solution in acetonitrile, 5.0 mmol). The reaction was agitated overnight at 80° C. and then concentrated to dryness to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06277877B1 |
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| Source dataset | uspto-grants-2001_08 |
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| ORD ID | ord-40966ff33508425da6d0f9cd2dc63164 |
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| Source note | uspto-grants-2001_08 |
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