L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- → HCID 69687358, compound

HRID 651195Notes

Reaction equation

HRID 651195 reaction equation
Cl.[OH:2][CH:3]1[CH2:6][NH:5][CH2:4]1.[CH3:7][C:8]([O:11][C:12]([NH:14][C@H:15]([C:23](O)=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:13])([CH3:10])[CH3:9]>>[C:8]([O:11][C:12](=[O:13])[NH:14][C@@H:15]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:23]([N:5]1[CH2:6][CH:3]([OH:2])[CH2:4]1)=[O:24])([CH3:10])([CH3:7])[CH3:9]

Participants

3

Reactant 2

HCID 77857L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-HCID 27592903-Hydroxyazetidine hydrochloride

Product 1

HCID 69687358HCID 69687358, compound

Procedure

3-Hydroxyazetidine hydrochloride (J. Chem. Soc., Chem. Commun. 1968, p93, 27 mmol) and N-t-Boc-L-phenylalanine (27 mmol) were coupled according to Procedure A giving the title substance as a colorless foam (8.15 g, 93%).

Sources & evidence

ORD record
ord-6edea7147a79407fb037085d28d7ac8e
Source dataset
uspto-grants-2001_08
Patent number
US06277877B1

Reaction notes

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