反应详情

Acetone (2.9 g) was added to sufficiently dehydrated toluene (500 ml) and the mixture was heated under reflux in a reaction flask equipped with a reflux condenser. While the reflux was continued, a warm solution obtained by dissolving formyl Meldrum's acid (8.6 g) in toluene (500 ml) on heating was dropwise added over about 2 hours, followed by subjecting the reaction mixture to heating under reflux for additional one hour and then subjecting the resulting reaction mixture to purifying operation in the same manner as in Example 1 to obtain 2,2-dimethyl-1,3-dioxin-4-one (5.3 g, yield 82%).

1. temperaturethe mixture was heated
2. temperatureunder reflux in a reaction flask
3. customequipped with a reflux condenser
4. customa warm solution obtained
5. temperatureon heating
6. additionwas dropwise added over about 2 hours
7. temperatureto heating
8. temperatureunder reflux for additional one hour
9. customthe resulting reaction mixture
10. customto purifying operation in the same manner as in Example 1