HCID 86757260, compound → HCID 86757259, compound

Participants

Reaction Steps

Next, benzo[a]pyrene-4-oxobutyric acid (compound 2b) was synthesized from compound 1b. Compound 1b (890 mg; 2.3 mmol) was dissolved in a mixture of dioxane (5 ml) and 2.4 N aqueous hydrochloric acid (5 ml), and the mixture was stirred for 6 hours under reflux with heating. The reaction mixture was extracted with dichloromethane, the organic layer was washed with water, and the solvent was then removed under a reduced pressure. The residue was washed with dichloromethane to obtain 555 mg (67% yield) of compound 2b as a position-isomer mixture.

Provenance & Evidence