HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 9904993, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-chloro-2-(4-fluorophenyl)quinazoline | HCID 4736855 | — |
| Reactant | HCID 178517500 | HCID 178517500 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 9904993 | HCID 9904993 | — |
Reaction Steps
4-Chloro-2-(4-fluorophenyl) quinazoline: 4-hydroxy-2-(4-fluorophenyl) quinazoline, from paragraph B, 1 equivalent, was suspended in chloroform and treated with 12 equivalents of thionyl chloride in the presence of a catalytic amount of dimethyl formamide, under reflux for 4 hours. After removal of the solvents under reduced pressure a solid was obtained that was analyzed by TLC. EIMS confirmed the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06277989B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-dda66af87374416a86eb738c0de0d163 |
| Source note | uspto-grants-2001_08 |