Pradofloxacin → Pradofloxacin Hydrochloride

HRID 651275Notes

Reaction equation

HRID 651275 reaction equation
[C:1]([C:3]1[C:4]([N:21]2[CH2:29][C@@H:28]3[C@@H:23]([CH2:24][CH2:25][CH2:26][NH:27]3)[CH2:22]2)=[C:5]([F:20])[CH:6]=[C:7]2[C:12]=1[N:11]([CH:13]1[CH2:15][CH2:14]1)[CH:10]=[C:9]([C:16]([OH:18])=[O:17])[C:8]2=[O:19])#[N:2].[ClH:30].O1CCOCC1>>[ClH:30].[C:1]([C:3]1[C:4]([N:21]2[CH2:29][C@@H:28]3[C@@H:23]([CH2:24][CH2:25][CH2:26][NH:27]3)[CH2:22]2)=[C:5]([F:20])[CH:6]=[C:7]2[C:12]=1[N:11]([CH:13]1[CH2:14][CH2:15]1)[CH:10]=[C:9]([C:16]([OH:18])=[O:17])[C:8]2=[O:19])#[N:2]

Participants

3

Reactant 2

HCID 9802884PradofloxacinHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 9802883Pradofloxacin Hydrochloride

Procedure

5.00 g (12.6 mmol) of 8-cyano-1-cyclopropyl-7-((1S,6S)-2,8-diazabicyclo[4.3.0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid are stirred in 95 ml of 4 N hydrochloric acid/dioxane (1:1) at 60° C. for two hours. The reaction mixture is concentrated in vacuo and the residue is recrystallized from ethanol.

Workup

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customthe residue is recrystallized from ethanol

Sources & evidence

ORD record
ord-1139986197ff4b54b1d012720b2cbf43
Source dataset
uspto-grants-2001_08
Patent number
US06278013B1

Reaction notes

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