Methyl vinyl ketone → HCID 70108429, compound

HRID 651281Notes

Reaction equation

HRID 651281 reaction equation
[C:1]([C:3]1[C:4]([N:21]2[CH2:29][C@@H:28]3[C@@H:23]([CH2:24][CH2:25][CH2:26][NH:27]3)[CH2:22]2)=[C:5]([F:20])[CH:6]=[C:7]2[C:12]=1[N:11]([CH:13]1[CH2:15][CH2:14]1)[CH:10]=[C:9]([C:16]([OH:18])=[O:17])[C:8]2=[O:19])#[N:2].[CH:30]([C:32]([CH3:34])=[O:33])=[CH2:31]>>[C:1]([C:3]1[C:4]([N:21]2[CH2:29][C@@H:28]3[C@@H:23]([CH2:24][CH2:25][CH2:26][N:27]3[CH2:31][CH2:30][C:32](=[O:33])[CH3:34])[CH2:22]2)=[C:5]([F:20])[CH:6]=[C:7]2[C:12]=1[N:11]([CH:13]1[CH2:14][CH2:15]1)[CH:10]=[C:9]([C:16]([OH:18])=[O:17])[C:8]2=[O:19])#[N:2]

Participants

3

Reactant 2

HCID 6570Methyl vinyl ketoneHCID 9802884Pradofloxacin

Product 1

HCID 70108429HCID 70108429, compound

Procedure

300 mg (0.76 mmol) of 8-cyano-1-cyclopropyl-7-((1S,6S)-2,8-diazabicyclo[4.3.0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 0.63 ml (7.6 mmol) of methly vinyl ketone are heated under reflux in 5 ml of methylglycol for 2 hours. The reaction solution is concentrated in vacuo and the residue is stirred with water and filtered off with suction.

Workup

  1. concentrationThe reaction solution is concentrated in vacuo
  2. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-d801728f4d534030acbb683c50229e46
Source dataset
uspto-grants-2001_08
Patent number
US06278013B1

Reaction notes

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