Water → 195532-64-0

HRID 651286Notes

Reaction equation

HRID 651286 reaction equation
[C:1]([C:3]1[C:4]([F:15])=[C:5]([CH:10]=[C:11]([F:14])[C:12]=1[F:13])[C:6]([O:8]C)=[O:7])#[N:2].O.S(=O)(=O)(O)O>C(O)(=O)C>[C:1]([C:3]1[C:4]([F:15])=[C:5]([CH:10]=[C:11]([F:14])[C:12]=1[F:13])[C:6]([OH:8])=[O:7])#[N:2]

Participants

5

Reactant 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 18417526Methyl 3-cyano-2,4,5-trifluoro-benzoate

Product 1

HCID 18417533195532-64-0

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 156 g of methyl 3-cyano-2,4,5-trifluoro-benzoate in a mixture of 960 ml of glacial acetic acid, 140 ml of water and 69 ml of concentrated sulphuric acid is heated to reflux for 8 hours. The acetic acid is distilled off and the resulting residue is treaten with water. The precipitate is filtered off with suction, washed with water and dried.

Workup

  1. temperatureis heated
  2. temperatureto reflux for 8 hours
  3. distillationThe acetic acid is distilled off
  4. filtrationThe precipitate is filtered off with suction
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-08f6237cbac2432d88c57f89817fb384
Source dataset
uspto-grants-2001_08
Patent number
US06278013B1

Reaction notes

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