反应详情

温度

30 °C

30 g of glacial acetic acid are added dropwise to the crude product from step e at 20° C. Then a solution of 15,75 g of cyclopropylamine in 30 ml of toluene is added dropwise. The reaction mixture is stirred at 30° C. for 1 hour. After the addition of 200 ml of water the mixture is stirred for 15 minutes. The organic phase is separated, extracted with 100 ml of water, dried with Na2CO3 and concentrated in vacuo. The crude product is used for the next step without further purification.

1. stirringis stirred for 15 minutes
2. customThe organic phase is separated
3. extractionextracted with 100 ml of water
4. dry with materialdried with Na2CO3
5. concentrationconcentrated in vacuo
6. customThe crude product is used for the next step without further purification