HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl alpha-oxobenzenebutanoate → Ethyl 2-hydroxy-4-phenylbutyrate, (+-)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl alpha-oxobenzenebutanoate | HCID 562087 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Toluene methanol | HCID 21867641 | — |
| Product | Ethyl 2-hydroxy-4-phenylbutyrate, (+-)- | HCID 4092621 | — |
Reaction Steps
The general procedure described in Example B1 is repeated, with the following modifications to the reaction conditions: ethyl-4-phenyl-2-oxobutyrate (substrate): 0.352 g (1.7 mmol); solvent: 10 ml of toluene/methanol (1:1); hydrogen: 50 bar, temperature: 50° C.; reaction time: 19 hours. The conversion is 100%, ee: 44% (R).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE037344E1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-2a15d83e4c9a44eea74e25d3e9238d39 |
| Source note | uspto-grants-2001_08 |