Chloroacetonitrile → HCID 24693597, compound

Participants

Reaction Steps

To a solution of 19.2 g (100 mmol) of commercially available 4-methoxyphenyl piperazine in acetonitrile (300 ml), 12.1 g (120 mmol) of triethylamine and 7.6 g (100 mmol) of chloroacetonitrile were subsequently added. The reaction mixture was refluxed for 2 hrs, cooled to room temperature and concentrated in vacuo. To the residue dichloromethane (300 ml) and water (150 ml) were added, the water layer was further extracted with dichloromethane (50 ml), the combined organic layers were dried over sodiumsulphate and concentrated in vacuo. In this manner 18.5 g of 1-(cyanomethyl)-4-(4-methoxyphenyl) piperazine (80%) was obtained as a white solid.

Provenance & Evidence