Benzyl Alcohol → HCID 70127773, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-methoxy-6-nitroaniline (2g; 0.0119 moles) in anhydrous THF (20 ml), trichloroethyl chloroformate (1.43 ml; 0.01189 moles) was added dropwise. The reaction was heated for 45 minutes at 60° C., the solvent was then removed under vacuum and the crude residue was dissolved in dioxane (20 ml). To this solution, benzyl alcohol (2.46 ml; 0.0237 mmoles) was added and the reaction mixture was refluxed for 8 hours. The solvent was then removed under vacuum and the crude residue was poured into diluted 10% HCl. The title compound was extracted into ethyl ether. The crude brown oil was crystallized with diisopropyl ether to give a light brown solid. 1.9 g; m.p. 78-80° C.

Provenance & Evidence