HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 6-Nitro-o-anisidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-Amino-3-Nitrophenol | HCID 4115495 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Nitro-o-anisidine | HCID 85491 | — |
Reaction Steps
To a mixture of 2-hydroxy-6-nitroaniline (41 g; 0.266 mol) and 85% KOH (17.5 g; 0.266 mol) in anhydrous DMF (80 ml), CH3I (16.5 ml; 0.266 mol) was added dropwise. The reaction mixture was stirred at room temperature for 4 hours then poured into ice-water, the title compound precipitated as a brown solid. 40 g; m.p. 67-68° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06281218B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-633658a5e57a4c82a413cccbea51478f |
| Source note | uspto-grants-2001_08 |