821-48-7 → HCID 21708342, compound

HRID 651383Notes

Reaction equation

HRID 651383 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][C:4]=1[C:10]([F:13])([F:12])[F:11].[Cl-].Cl[CH2:16][CH2:17][NH2+:18][CH2:19][CH2:20]Cl>C(O)CCC>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:5][C:4]=1[C:10]([F:11])([F:12])[F:13]

Participants

4

Reactant 2

HCID 13186821-48-7HCID 6007055-Amino-2-methoxybenzotrifluoride

Product 1

HCID 21708342HCID 21708342, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 4-methoxy-3-trifluoromethylphenylamine (12 g; 0.0627 mol) and bis(2-chloroethyl) ammonium chloride (11.2 g; 0.0627 mol) in n-butanol (120 ml) was refluxed for 10 hours. The reaction mixture was cooled at room temperature and the crude title compound precipitated as hydrochloride salt overnight. The solid was collected and crystallized from acetone. 7 g; m.p. 244-245° C.

Workup

  1. temperaturewas refluxed for 10 hours
  2. customthe crude title compound precipitated as hydrochloride salt overnight
  3. customThe solid was collected
  4. customcrystallized from acetone

Sources & evidence

ORD record
ord-77065d2ad7124cfb88d36133bbc78dd1
Source dataset
uspto-grants-2001_08
Patent number
US06281218B1

Reaction notes

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