4-Bromophenacyl bromide → 4-(4-Bromo-phenyl)-2-(4-fluoro-phenyl)-thiazole

Participants

Reaction Steps

To a solution of p-fluorothiobenzamide (0.39 g, 2.5 mmol) in 20 mL of abs. EtOH is added 2,4′-dibromoacetophenone (0.7 g, 2.5 mmol) all at once. The reaction mixture is stirred at room temperature for 3 hours and then chilled in ice bath. The precipitate is collected by filtration, washed with cold EtOH (5 ml×2) and dried in vacuum to give 2-(4′-fluorophenyl)-4-(4′-bromophenyl)thiazole as a white fluffy crystaline solid (1.55 g, 93%). mp.158-9° C. 1H NMR (CDCl3): δ 7.16 (t, 2H), 7.47 (s, 1H), 7.58 (d, 2H), 7.87 ()d, 2H), 8.02 (m, 2H).

Provenance & Evidence