HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl N-methylaminoacetate hydrochloride → N-Methyl-N-[2-(2,4,6-trimethylphenyl)-2-cyanovinyl]-glycine ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl N-methylaminoacetate hydrochloride | HCID 171173 | — |
| Reactant | 3-Oxo-2-(2,4,6-trimethyl-phenyl)-propionitrile | HCID 22474397 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | N-Methyl-N-[2-(2,4,6-trimethylphenyl)-2-cyanovinyl]-glycine ethyl ester | HCID 54495113 | — |
Reaction Steps
A mixture of a-formyl-2,4,6 trimethylphenylacetonitrile (4.5 g, 24 mmol) and sarcosine ethyl ester hydrochloride (3.7 g, 24 mmol) in 100 mL of benzene was refluxed in a Dean-Stark apparatus for 16 h. The solvent was removed in vacuo to afford N-Methyl-N-[2-(2,4,6-trimethylphenyl)-2-cyanovinyl]-glycine ethyl ester as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06281220B1 |
| Source dataset | uspto-grants-2001_08 |
| ORD ID | ord-ead9c95c832242898a8f79eb80acd3ee |
| Source note | uspto-grants-2001_08 |