Water → HCID 21708411, compound

Participants

Reaction Conditions

Reaction Steps

4-Chloro-6-(N-methyl-3-trifluoromethylanilino)-pyrimidine (0.30 g, 0.001 mol.) and sodium carbonate (0.28 g, 0.003 mol.) in DMF are stirred for 10 minutes. m-Trifluoro-methylphenol (0.16 g, 0.001 mol) is added and the mixture is heated to 60° C. for 12 hours. The mixture is then cooled and poured into water. The product is extracted into ethyl acetate, washed with 10% sodium hydroxide, 10% hydrochloric acid, and 5% potassium carbonate, dried over Na2SO4, filtered, and is concentrated under reduced pressure. 6-(N-methyl-3-trifluoromethylanilino)-4-(3-trifluoromethyl-phenoxy)pyrimidine (0.16 g) obtained by chromatography as a white solid. M.p. 118-119° C.

Provenance & Evidence