Ethanol → HCID 21708397, compound

Participants

Reaction Steps

2-(Ethylsulfonyl)-4-[m-(trifluoromethyl)benzyl] -6-[(α,α,α-trifluoro-m-tolyl)oxy]pyrimidine (1.17 g, 2.4 mmol) is added to chloroform (10 ml) and ethanol (10 ml). sodium borohydride (0.3 g, 7.9 mmol) is added portionwise over 15 minutes and the reaction is stirred at room temperature for 80 mins. The mixture is taken up in ethyl acetate and is washed with water, brine and dried over magnesium sulfate. The solvent is evaporated to give 1.05 g of a cloudy oil which is chromatographed to yield 0.89 g 4-[m-(trifluoromethyl)benzyl]-6-[(α,α,α-trifluoro-m-tolyl)oxy]pyrimidine as a water white oil. 1H NMR CDCl3 4.17 (2H, s) 6.75 (1H,s) 7.3-7.6 (8H, m) 8.71 (1H, s)

Provenance & Evidence