反应详情

1.4 g of 2,6-dichloro-4-pyridinemethanol were dissolved into 5 ml of pyridine, and the solution was cooled by ice. To this, 1.5 g of 2-nitrobenzoyl chloride, which was prepared from 2-nitrobenzoic acid and thionyl chloride, were added dropwise. After the reacted solution was stirred for 2 hours, dichloromethane was added. The organic phase was washed with water, and was dried by adding sodium sulfate. The solvent was removed by evaporation, and the residue was purified by silica gel column chromatography to obtain 1.4 g of (2,6-dichloro-4-pyridinyl)methyl 2-nitrobenzoate ester (Compound No. 69).

1. temperaturethe solution was cooled by ice
2. additionwere added dropwise
3. washThe organic phase was washed with water
4. customwas dried
5. additionby adding sodium sulfate
6. customThe solvent was removed by evaporation
7. customthe residue was purified by silica gel column chromatography