HRID651434

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C1CCC(N2Cc3c(cccc3[N+](=O)[O-])C2=O)C(=O)N1

HCID11471781

3-(4-Nitro-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione

C13H11N3O5

结构：O=C1CCC(N2Cc3cc([N+](=O)[O-])ccc3C2=O)C(=O)N1

HCID21928277

未命名化合物

PRODUCTS

生成物

结构：O=C1CCC(N2Cc3ccc([N+](=O)[O-])cc3C2=O)C(=O)N1

HCID21928265

未命名化合物

结构：O=C1CCC(N2Cc3cccc([N+](=O)[O-])c3C2=O)C(=O)N1

HCID21928273

未命名化合物

PROCEDURE

实验过程

1-Oxo-2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline, 1-oxo-2-(2,6-dioxopiperidin-3-yl )-4-nitroisoindoline. 1-oxo-2-(2,6-dioxopiperidin-3-yl)-6-nitroisoindoline, and 1-oxo-2-(2,6-dioxopiperidine-3-yl)-7-nitroisoindoline can be obtained by allowing 2,6-dioxopiperidin-3-ammonium chloride to react with methyl 2-bromomethyl-5-nitrobenzoate, methyl 2-bromomethyl-4-nitrobenzoate methyl 2-bromomethyl-6-nitrobenzoate, and methyl 2-bromomethyl-7-nitrobenzoate, respectively, in dimethylformamide in the presence of triethylamine. The methyl 2-(bromomethyl)nitrobenzoates in turn are obtained from the corresponding methyl esters of nitro-orthotoluic acids by conventional bromination with N-bromosuccinimide under the influence of light.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-95a0ff761e034287a423649da67bdc38
来源数据集: uspto-grants-2001_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06281230B1
来源说明: uspto-grants-2001_08

反应 SMILES

[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=2)[CH2:4][N:3]1[CH:14]1[CH2:19][CH2:18][C:17](=[O:20])[NH:16][C:15]1=[O:21].[O:22]=[C:23]1[C:31]2[C:26](=[C:27]([N+:32]([O-:34])=[O:33])[CH:28]=[CH:29][CH:30]=2)[CH2:25][N:24]1[CH:35]1[CH2:40][CH2:39][C:38](=[O:41])[NH:37][C:36]1=[O:42]>>[O:22]=[C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=2)[CH2:2][N:3]1[CH:14]1[CH2:19][CH2:18][C:17](=[O:20])[NH:16][C:15]1=[O:21].[O:1]=[C:25]1[C:26]2[C:31](=[CH:30][CH:29]=[CH:28][C:27]=2[N+:32]([O-:34])=[O:33])[CH2:23][N:24]1[CH:35]1[CH2:40][CH2:39][C:38](=[O:41])[NH:37][C:36]1=[O:42]