HCID 54445383, compound → HCID 15379686, compound

HRID 651442Notes

Reaction equation

HRID 651442 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[C:3](=[C:9]([C:15]#[N:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:2]2.[H][H]>C(O)C.[Pd]>[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([CH:9]([C:15]#[N:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:2]2

Participants

5

Reactant 2

HCID 54445383HCID 54445383, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15379686HCID 15379686, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of ethyl (1-azabicyclo[2.2.2]octan-3-ylidene)cyanoacetate (73 g, 0.33 mol) in absolute ethanol (1 l) was treated with 10% palladium on charcoal (10 g) and hydrogen in a parr shaker at 20 psi for 5 h. Filtration and evaporation gave the wanted product in 68 g yield.

Workup

  1. filtrationFiltration and evaporation
  2. customgave the wanted product in 68 g
  3. customyield

Sources & evidence

ORD record
ord-44b5e8b332474216b57e778d19ecb8ad
Source dataset
uspto-grants-2001_08
Patent number
US06281233B1

Reaction notes

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