反应详情

The monosilylated diol of Step 2 was hydrogenated with 5% Rh-C at 60 psi and 60° C. in MeOH (135 mL). The mixture was filtered and the filtrate evaporated. The residue was purified by chromatography, eluting with (15% EtOAc in hexane) to give the title alcohol (8.70 g, 67% yield, mp 61-63° C). The 1H, 13C, and APT NMR spectral data were consistent with the proposed product.

1. filtrationThe mixture was filtered
2. customthe filtrate evaporated
3. customThe residue was purified by chromatography
4. washeluting with (15% EtOAc in hexane)