Imidazole → HCID 70234588, compound

Participants

Reaction Steps

A solution of 7.4 mmol of the compound of Example 14, 58.8 mmol of imidazole and 13 mmol of tert-butyldimethylsilyl chloride in 225 ml of anhydrous dimethylformarnide is stirred at ambient temperature. After reaction for 17 hours, the mixture is poured into a mixture of water and ether. After exraction with ether, the combined organic phases are dried, filtered and then concentrated under reduced pressure. The residue is subsequently recrystallised from a heptane/benzene mixture enabling the expected product to be isolated.

Provenance & Evidence