HCID 21987688, compound → HCID 21708852, compound

Participants

Reaction Steps

Ten grams (30.9 mmols) of crude 2-(3′-N,N-diethylaminomethyl-2′-hydroxy-5′-methylphenyl)-2H-benzotriazole obtained following the procedures of Synthesis Example 1 and 9.57 g (30.9 mmols) of 2-(2′-hydroxy-5′-acryloyloxyethylphenyl)-2H-benzotriazole were dissolved in 64 ml of xylene, and 1.5 ml of a 28% sodium methylate•methanol solution were added thereto. The mixture was then refluxed in a nitrogen stream for 10 hours. After the completion of the reaction, the reaction mixture was cooled to room temperature. Yellow crystals precipitated at this stage were separated through filtration, and recrystallized from chloroform to obtain 11.8 g of 6-(2H-benzotriazol-2-yl)-4-acryloyloxyethyl-2-[3′-(2H-benzotriazol-2-yl)-2′-hydroxy-5′-methylphenyl]methylphenol (hereinafter abbreviated as “RUVA-4”) as white crystals (yield 69.1%, purity 99.0%).

Provenance & Evidence