HCID 20680528, compound → HCID 20680559, compound

HRID 651585Notes

Reaction equation

HRID 651585 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].NC1C2C(=CC(CN3CC[C@@H](NC([NH:28][C:29]4S[C:31]([Cl:34])=[CH:32][CH:33]=4)=O)C3=O)=CC=2)N=CN=1.FC(F)(F)C(O)=O.[NH2:43][C:44]1[C:53]2[C:48](=[CH:49][C:50]([CH2:54][N:55]3[CH2:59][CH2:58][C@@H:57]([NH:60][C:61]([C:63]4S[C:65](Cl)=[CH:66][CH:67]=4)=O)[C:56]3=[O:69])=[CH:51][CH:52]=2)[N:47]=[CH:46][N:45]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH2:43][C:44]1[C:53]2[C:48](=[CH:49][C:50]([CH2:54][N:55]3[CH2:59][CH2:58][C@@H:57]([NH:60][CH2:61][C:63]4[NH:28][C:29]5[C:66]([CH:67]=4)=[CH:65][C:31]([Cl:34])=[CH:32][CH:33]=5)[C:56]3=[O:69])=[CH:51][CH:52]=2)[N:47]=[CH:46][N:45]=1

Participants

3

Reactant 2

HCID 20680528HCID 20680528, compoundHCID 70123235HCID 70123235, compound

Product 1

HCID 20680559HCID 20680559, compound

Procedure

1-[1-(4-Aminoquinazolin-7-ylmethyl)-2-oxopyrrolidin-3-(R)-yl]-3-(5-chlorothiophen-2-yl)urea trifluoroacetate and 5-Chlorothiophene-2-carboxylic acid [1-(4-aminoquinazolin-7-ylmethyl)-2-oxopyrrolidin-3-(R)-yl]amide trifluoroacetate;

Sources & evidence

ORD record
ord-74c7f64a9d304942b09240ef9dd7a764
Source dataset
uspto-grants-2001_08
Patent number
US06281227B1

Reaction notes

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