反应详情

温度

180 °C

Iodine (0.63 g, 2.51 mmol) is added to a solution of 1-(2-isocyanato-vinyl)-4-methyl-benzene (ca. 20 g, 125.6 mmol) in o-dichlorobenzene (125 mL), then is heated to reflux (180° C.) overnight. The mixture is cooled to room temperature then concentrated to dryness. The residue is purified by column chromatography eluting with 40% EtOAc/hexanes. The product (6.23 g, 39.1 mmol) is obtained as a tan solid.

1. temperatureis heated
2. temperatureThe mixture is cooled to room temperature
3. concentrationthen concentrated to dryness
4. customThe residue is purified by column chromatography
5. washeluting with 40% EtOAc/hexanes