反应详情

To a suspension of 6-(3,4-dimethoxyphenyl)-3-methyl-2,4(1H,3H)-pyrimidinedione (1.5 g) in dioxane (15 ml) was added phosphorus pentasulfide (1.27 g) and the mixture was refluxed for 2 hours. After being cooled, ethanol (15 ml) was added thereto, and the mixture was refluxed for 2 hours again. After being cooled, the resulting precipitates were collected by filtration and washed successively with ethanol and diisopropyl ether to give 3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-thioxo-2(1H)-pyrimidinone (0.85 g).

1. temperaturethe mixture was refluxed for 2 hours
2. temperatureAfter being cooled
3. temperaturethe mixture was refluxed for 2 hours again
4. temperatureAfter being cooled
5. customthe resulting precipitates
6. filtrationwere collected by filtration
7. washwashed successively with ethanol and diisopropyl ether