7-methoxynaphthalene-2-sulfonyl Chloride → HCID 54426371, compound

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Reaction Steps

The title compound is prepared in CH2Cl2 instead of CH3CN as described in EXAMPLE 1, Part K using 5-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)-2-chloro-quinoline hydrochloride in place of 7-(3-(S)-amino-2oxopyrrolidin-1-ylmethyl)-1-chloro-isoquinoline hydrochloride and 7-methoxynaphthalene-2-sulfonyl chloride as prepared in EXAMPLE 1, Part J. The crude product is purified by column chromatography eluting with 25% EtOAc/CH2Cl2 to provide the title compound as a light yellow solid.

Provenance & Evidence