7-methoxynaphthalene-2-sulfonyl Chloride → HCID 53996787, compound

HRID 651618Notes

Reaction equation

HRID 651618 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[N:15]=[C:14]([Cl:19])[CH:13]=[CH:12]3)[C:4]1=[O:20].[CH3:21][O:22][C:23]1[CH:32]=[C:31]2[C:26]([CH:27]=[CH:28][C:29]([S:33](Cl)(=[O:35])=[O:34])=[CH:30]2)=[CH:25][CH:24]=1>C(Cl)Cl>[Cl:19][C:14]1[CH:13]=[CH:12][C:11]2[C:16](=[CH:17][CH:18]=[C:9]([CH2:8][N:5]3[CH2:6][CH2:7][C@H:3]([NH:2][S:33]([C:29]4[CH:28]=[CH:27][C:26]5[C:31](=[CH:32][C:23]([O:22][CH3:21])=[CH:24][CH:25]=5)[CH:30]=4)(=[O:35])=[O:34])[C:4]3=[O:20])[CH:10]=2)[N:15]=1

Participants

4

Reactant 2

HCID 105152667-methoxynaphthalene-2-sulfonyl ChlorideHCID 20680737HCID 20680737, compound

Product 1

HCID 53996787HCID 53996787, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound is prepared in CH2Cl2 instead of CH3CN as described in EXAMPLE 1, Part K using 6-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)-2-chloro-quinoline hydrochloride as the starting material and 7-methoxynaphthalene-2-sulfonyl chloride. The crude product is triturated in CH2Cl2 and filtered to provide the title compound as a white solid.

Workup

  1. customThe crude product is triturated in CH2Cl2
  2. filtrationfiltered

Sources & evidence

ORD record
ord-6dcaabcb21fc4179bd63fd73676310c7
Source dataset
uspto-grants-2001_08
Patent number
US06281227B1

Reaction notes

Loading…