7-methoxynaphthalene-2-sulfonyl Chloride → HCID 54088991, compound

Participants

Reaction Steps

The title compound is prepared in CH2Cl2 instead of CH3CN as described in EXAMPLE 1, Part K using 3-(S)-amino-1-(4-amino-3-nitrobenzyl)-pyrrolidin-2-one in place of 7-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)-1-chloro-isoquinoline hydrochloride and 7-methoxynaphthalene-2-sulfonyl chloride as prepared in EXAMPLE 1, Part J. The crude product is purified by column chromatography eluting with a gradient of 20% EtOAc/CH2Cl2 to 50% EtOAc/CH2Cl2 to afford the title compound as a pale yellow solid.

Provenance & Evidence